Punk not dead
adalat ppt Lipodystrophy is characterized by selective loss of adipose tissue that leads to a deficiency of adipose-derived hormones, particularly leptin, which is a major regulator of appetite and energy regulation. In turn, leptin deficiency leads to hyperphagia, which results in an accumulation of ectopic fat in tissues such as the muscles and the liver. Because of this, many patients develop severe insulin resistance, diabetes, and hypertriglyceridemia.