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ursodiol cost Three contrasting factors then shifted the ground once more. Firstly, the Globe opened in 1997, and began to present Shakespeare according to traditional practices. With that so beautifully taken care of, other directors could push out in new ways. Then Michael Boyd took over the direction of the RSC from Adrian Noble in 2003, and immediately began to redefine the nature of Shakespeare productions, culminating in his visceral and unforgettable ensemble Histories in 2003. (This is a path his associate, Gregory Doran, continues to develop.)